scleroderma
Conditions
Interventions
Experimental Group A:Traditional fat grafting and sequential injection of adipose stromal vascular components/adhesive extracellular matrix
Experimental Group B:Traditional fat grafting
Sponsors
Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign informed consent; 2. Aged 18-59 years, gender unlimited; 3. The BMI > = 17; 4. Patients with clinically confirmed localized/systemic scleroderma did not have severe internal organ involvement.
Exclusion criteria
Exclusion criteria: 1. Surgical contraindications; 2. Pregnant or breastfeeding; 3. New vasodilators or immunosuppressive drugs within 3 months; 4. Apply topical ointment to the surgical area within 2 weeks; 5. HIV, HBV or HCV, HTLV-1 or -2, syphilis positive; 6. Patients with a history of tumor formation in the last 5 years; 7. Patients with prednisolone intake greater than 10 mg/d; 8. Patients deemed unsuitable for the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Localized Scleroderma Skin Damage Index (LoSDI) ;modified localized scleroderma skin severity index (mLoSSI); | — |
Secondary
| Measure | Time frame |
|---|---|
| modified Rondnan Skin Score (mRSS); | — |
Countries
China
Contacts
Public ContactLu Feng
Nanfang Hospital, Southern Medical University
Outcome results
None listed