Infertility
Conditions
Interventions
Natural cycles group:Natural ovulation regimen for frozen embryo transfer
Programmed cycles group:Programmed regimen for frozen embryo transfer
Sponsors
Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Women with regular menstrual cycles, which are defined as the length of the menstrual cycle ranging from 24 to 38 days. 2. Women aged >= 20 and <= 40 years. 3. Women who are planning to receive a single frozen-thawed blastocyst transfer, which was derived from IVF cycles, ICSI cycles, or PGT-A cycles. 4. Women with at least one vitrified blastocyst in storage for IVF or ICSI cycles, or one euploid blastocyst for PGT-A cycles; the blastocyst was morphologically graded as 4BC or better using Gardner grading criteria and was cryopreserved on Day 5 or Day 6 of embryo culture.
Exclusion criteria
Exclusion criteria: 1. Women who failed to achieve clinical pregnancy after two or more previous cycles of embryo transfer. 2. Women whose embryos are derived from oocyte donation, frozen oocyte, or embryos that have undergone thawing and re-cryopreservation process. 3. Women with a history of intrauterine adhesion or with untreated submucosal uterine fibroids. 4. Women with untreated hydrosalpinx that is visible under pelvic ultrasound. 5. Women with a history of cycle cancellation due to thin endometrium (<7mm). 6. Anti-phospholipid antibody syndrome, systemic lupus erythematosus, or rheumatologic disease that requires chronic systemic medications. 7. Women who have contraindications for estrogen and progesterone administration (e.g., breast cancer, or risks of venous thromboembolism).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healthy live birth rate;Incidence of preeclampsia/eclampsia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cycle cancellation rate;Conception rate;Clinical pregnancy rate;Pregnancy loss rate;Live birth rate;Birth weight;Incidence of neonatal complications;Incidence of other adverse events;Incidence of hypertensive disorders of pregnancy;Incidence of gestational diabetes;Incidence of placenta previa;Incidence of placental abruption;Incidence of placenta accreta spectrum;Incidence of premature rupture of membrane;Incidence of stillbirth;Incidence of postpartum hemorrhage;Incidence of preterm birth; | — |
Countries
China
Contacts
Public ContactZi-Jiang Chen
Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University
Outcome results
None listed