Developmental dysplasia of the hip
Conditions
Interventions
None listed
Sponsors
Chinese PLA general hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. In the same family, two or more immediate family members have DDH (clearly diagnosed by two orthopedic surgeons with senior professional titles on imaging); 2. Aged 18-85; 3. Hip joint X-ray screening and peripheral blood sample sampling; 4. Patients voluntarily participated in the study and signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Imaging examination ruled out DDH diagnosis; 2. Severe diseases of the blood system, such as hemolysis, myelodysplastic syndrome, coagulation related diseases, etc.; 3. There is no healthy control in the immediate family; 4. The researcher considers it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Statistics of the number of gene mutation sites;Statistical distribution of single nucleotide mutation types;Number statistics and locus distribution of DDH-related susceptible genes;Related molecular pathways and cell component statistics involving mutated genes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Imaging records;DDH typing; | — |
Countries
China
Contacts
Public ContactWei Chai
Chinese PLA general hospital
Outcome results
None listed