Brain edema after meningioma surgery
Conditions
Interventions
Ulinastatin exposed group:None
Non-exposed group:None
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-64 years old; 2. ASA (American Society of Anesthesiologists) physical status I or II grade; 3. BMI 18-30kg/m^2; 4. Patients with benign meningioma (WHO I), undergo meningioma resection for the first time; 5. Right-handed; 6. Willing to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of pre-existed delayed anesthesia recovery or cognitive impairment; 2. Consciousness altering caused by the tumor before surgery; 3. History of allergy to anesthetic agents or ulinastatin; 4. Multiple or recurrent meningiomas; 5. Unable to undergo NSTs or preoperatively demention assessed via MMSE, or CDR > 0; 6. Preoperative intracranial hypertension or infection requiring immediate treatment, or history of previous brain surgery; 7. Heart, hepatic, lung, and renal dysfunction; 8. Contraindications for MRI; 9. Pregnant and lactant women; 10. Non-right-handed or refusal to enroll in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of brain edema by magnetic resonance imaging indicator; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ICU stay;Blood inflammatory markers;postoperative length of stay;Extubation time;Changes of brain function;BBB related indicators;Neuropsychological Scale Tests (MoCA,etc.);Incidences of adverse reactions or complications after surgery;Muscle strength score and VAS;ADL;MMSE;CDR;Education level;Operation and anesthesia time;Tumor characteristics (Size/Location/Classification/Complication);fluid input and loss during surgery;Dosages of anti-inflammatory and anti-edema drugs during and after surgery;Age;BMI; | — |
Countries
China
Contacts
Public ContactTianlong Wang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed