Wet Age-related Macular Degeneration
Conditions
Interventions
None listed
Sponsors
Shaanxi Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 50 years old; 2. The central visual acuity decreases slowly, there may be visual object deformation, there is gaze shadow in front, and finally, the central visual acuity is lost; 3. Fundus photography shows clearly defined non-hemoglobin or hard exudated yellowish white protruding material; FA showed low fluorescence plaque under early occlusion and high fluorescence without leakage in late stage; OCT showed subretinal hyperreflexive lesions, which may be accompanied by adjacent RPE and elliptical zone loss. Octa provided noninvasive evaluation of blood flow in fibrotic choroidal neovascularization. A variety of ophthalmic examinations were consistent with the performance of multimodal imaging of subretinal fibrosis.
Exclusion criteria
Exclusion criteria: 1. Any previous history of eye trauma, surgery, laser treatment, etc; 2. Other diseases that cause ocular fundus disease (glaucoma, retinal vascular obstruction and diabetic retinopathy); 3. The refractive stroma is obviously turbid and cannot cooperate with the examination; 4. Other fibrosis-causing diseases (diabetic retinopathy, vitreous body retinopathy).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine concentration in Aqueous humor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Uncorrected visual acuity;Best corrected visual acuity;Intraocular Pressure;Subretinal hyperreflective material thickness; | — |
Countries
China
Contacts
Public ContactJing Li
Shaanxi Provincial People's Hospital
Outcome results
None listed