Breast cancer
Conditions
Interventions
Experimental group:0.3 mg/kg s-esketamine
Control group:0.3 ug/kg sufentanil
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients and their legal representatives voluntarily participate in the research and sign the informed consent; 2. Patients who underwent modified radical mastectomy or total mastectomy in our hospital; 3. American Society of Anesthesiologists (ASA) classification I-II, aged 18-70 years, BMI 18-30 kg/m2; 4. Have not participated in clinical trials of other drugs within 3 months before screening.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to dex-ketamine or any of the ingredients or excipients of this preparation; 2. Combination of other vital organ dysfunctions: including severe liver and kidney dysfunction; organic brain diseases, specifically aneurysmal vascular disease or arteriovenous malformation and cerebral hemorrhage; severe hypertension, coronary heart disease, cardiac insufficiency (NYHA >= grade III), pulmonary hypertension; blood system diseases; abnormal coagulation function; severe respiratory system diseases; 3. Patients with preoperative behavior disorder or combined mental illness who have used psychotropic drugs; 4. Have a history of abuse of illegal drugs such as ecstasy and ketamine; 5. Those with a history of alcohol or drug dependence; 6. Chemotherapy has been performed before surgery; 7. Patients deemed unsuitable for inclusion by other investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-rating anxiety scale (SAS scale) score;Postoperative patient depression SDS rating; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of patients' vital signs during perioperative period;5-year recurrence-free survival;5-year overall survival after surgery;Adverse reactions; | — |
Countries
China
Contacts
Public ContactHei Ziqing
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed