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Low-dose naloxone combined with ropivacaine in thoracolumbar interfascial plane block for postoperative analgesia in lumbar spinal fusion surgery

Low-dose naloxone combined with ropivacaine in thoracolumbar interfascial plane block for postoperative analgesia in lumbar spinal fusion surgery

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200057940
Enrollment
Unknown
Registered
2022-03-23
Start date
2022-04-01
Completion date
Unknown
Last updated
2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Herniated lumbar discs

Interventions

Group 1:0.75% ropivacaine 10 mL + 0.9% saline 10 mL, 20 mL into each side
Group 2:0.75% ropivacaine 10 mL + 0.9% saline 9 mL + 100 ng naloxone 1 mL, 20 mL into each side

Sponsors

Second Hospital of Lanzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) Health Status Grade I-III; 2. Age 40-70 years; 3. Patients (1-3 levels) who were to undergo posterior median approach lumbar fusion under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. History of lumbar trauma or lumbar surgery; 2. Puncture site infection, ulceration and tumor; 3. Obese patients with difficulty in ultrasound localization; 4. Local anesthetic allergy; 5. Abnormal coagulation function; 6. History of chronic pain and opioid dependence; 7. Patients with neurological diseases or neurological dysfunction; 8. Refusing to participate in the study.

Design outcomes

Primary

MeasureTime frame
Postoperative VAS pain scores at rest and on turning;

Countries

China

Contacts

Public ContactQingyang Yan

Second Hospital of Lanzhou University

18863633031@163.com+86 18109316979

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026