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Clinical Observation of Autologus Platelet-rich Fibrin Aided Revascularization in Mature Permanent Teeth

Clinical Observation of Autologus Platelet-rich Fibrin Aided Revascularization in Mature Permanent Teeth

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200057887
Enrollment
Unknown
Registered
2022-03-20
Start date
2019-01-01
Completion date
Unknown
Last updated
2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulp periapical periodontitis

Interventions

experimental group:PRF-assisted
control group:Root bleeding

Sponsors

Stomatological Hospital of Xiamen Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: 1. The patient is 18-30 years old; 2. Dental pulp necrosis with immature root tip development: The tooth development is in the 7th, 8th or 9th stage of Nolla stage. The Nolla staging method is as follows: Stage 0: no dental follicle; Stage 1: appearance of dental sac; Stage 2: apical calcification; Stage 3: 1/3 crown formation; Stage 4: 2/3 of crown formation; Stage 5: the crown was nearly formed; Stage 6: crown formation and root development; Stage 7: root formation 1/3; Stage 8: root formation 2/3; Stage 9: The root was nearly formed, and the apical foramen were not closed; Stage 10: root formation and apical foramen closure; 3. Adult permanent teeth with mature root development but root tip absorption and destruction, and apical aperture diameter greater than 1mm; 4. There is no need to leave space for the post/core final restoration; 5. Anterior teeth or premolars of single root canal; 6. The patient and his guardian agree to the treatment plan, sign the informed consent form and have good compliance; 7. The patient is not allergic to the drugs and antibiotics needed to complete the treatment; 8. There is no periodontal disease or root fissure.

Exclusion criteria

Exclusion criteria: 1. Patients with other serious organ diseases, such as heart, lung, kidney and other major diseases; 2. Patients with apical cyst; 3. Patients who do not cooperate or withdraw.

Design outcomes

Primary

MeasureTime frame
apical foramen size;root length;root thickness;pulpal vitality;

Countries

China

Contacts

Public ContactZhaojun Wu

Stomatological Hospital of Xiamen Medical College

wzj445733797@hotmail.com+86 59 22678533

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026