total hip and knee arthroplasty
Conditions
Interventions
Group A:No postoperative TXA
Group B:1.5g TXA i.v. q12h from postoperative days 1 to 3
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 18 years old; 2.Patients who need hip and knee arthroplasty in the Department of orthopedics of our hospital.
Exclusion criteria
Exclusion criteria: 1. Complicated with serious cardiovascular and cerebrovascular diseases (myocardial infarction, cerebral infarction, etc.); 2. Have obvious bleeding tendency (such as active gastrointestinal bleeding, cerebral hemorrhage, etc.); 3. Complicated with systemic or local venous thromboembolism (such as deep venous thrombosis, pulmonary embolism, etc.); 4. Previously identified coagulation dysfunction; 5. Complicated with severe neuromuscular system diseases; 6. Allergy to tranexamic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hidden blood loss (HBL);decline of hemoglobin level;Transfusion rate;Transfusion volume;Thromboelastogram(TEG); | — |
Secondary
| Measure | Time frame |
|---|---|
| Routine coagulation parameters(PT?PTR?INR?PTA?APTT?TT);Routine fibrinolysis parameters(FDP?D-D);Wound complications (exudation, hematoma, infection);Incidence of venous thromboembolism (DVT, PE);90-day mortality after surgery; | — |
Countries
China
Contacts
Public ContactWei Huang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed