mild cognitive impairment
Conditions
Interventions
Control group:basic disease treatment + placebo
Placebo twice a day, 3 tablets after meal
Treatment group:basic disease treatment + zhinaoshen (tablet)
Zhinaoshen tablet twice a day, 3 tablets after meal
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Science
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age = 40 years and = 80 years; 2. The ability of daily living is normal, that is, the ADL score is = 18 points; 3. Impaired objective cognitive function: the cut-off value of the Montreal cognitive assessment basic (MoCA-B) is: education background less than 6 years, = 19 points; Education background: 7-12 years, = 22 points; Education background of more than 12 years, = 24 points; 4. No dementia, that is, the overall decline scale (GDS) is rated as 2-3; 5. TCM syndrome differentiation is Qi deficiency and blood stasis syndrome; 6. The Chinese and western medicine therapy was not regularly applied to cognitive function in recent 2 months; 7. Informed consent and voluntary participation.
Exclusion criteria
Exclusion criteria: 1. Hypertension patients with uncontrollable blood pressure (systolic blood pressure greater than 160mmHg or diastolic blood pressure greater than 100mmHg); 2. Have a history of alcohol and drug abuse; 3. Have a history of mental illness (such as personality disorder, schizophrenia, etc.), or suffer from severe aphasia and audio-visual disorder, or severe organ failure, myocardial infarction, coronary heart disease, musculoskeletal system disease, and other sports contraindications; 4. Cognitive impairment caused by depression, namely, the Elderly Depression Scale (ODS) = 11 points; 5. People with cognitive impairment caused by drugs or poisoning; 6. Oral antibiotics, probiotics and/or prebiotics within 1 months; 7. Other clinical trials who are participating in the evaluation of the research results; 8. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (Montreal Cognitive Assessment;Alzheimer's disease rating scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Activity of daily living rating scale; | — |
Countries
China
Contacts
Public ContactLinjuan Sun
Xiyuan Hospital of China Academy of Chinese Medical Science
Outcome results
None listed