syphilis
Conditions
Interventions
Drug intake group:Take 200mg of doxycycline within 24 hours of high-risk behavior.After a cumulative weekly dose of 600mg, they stopped taking the drug this week. Have syphilis/HIV test every two mont
Control group:Have syphilis/HIV test every two months
Sponsors
Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. Not infected with syphilis or HIV; 3. The person who is male at birth and has experience of male sexual behavior, and has one or more of the following dangerous sexual behaviors 6 months before selection: 1) Having unprotected sex; 2). The total number of sexual partners in the first 6 months was 2 or more; 3). Self reported sexually transmitted diseases, such as genital herpes, gonorrhea, chlamydia infection, chancroid, or venereal lymphogranuloma, in addition to AIDS and syphilis; 4) Have experience of preventive medication before or after HIV exposure; 4. No medication history of doxycycline in recent six months; 5. After comprehensive clinical examination (including regular examination, urine, blood examination, etc.), there is no serious liver and kidney dysfunction, and the detection of hepatitis B surface antibody and hepatitis C antibody is negative, and other indicators are normal; 6. Those who voluntarily participate in the study and sign the informed consent form after fully understanding the purpose, design and possible outcomes of the trial.
Exclusion criteria
Exclusion criteria: 1. Allergic constitution or allergy to tetracycline components; 2. Patients with serious chronic diseases, metabolic diseases (such as diabetes), and neuropsychiatric disorders; 3. Unsuitable individuals (such as illness or poor compliance).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| syphilis incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| chlamydia trachomatis infection incidence;HIV incidence; | — |
Countries
China
Contacts
Public ContactQianqiu Wang
Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College
Outcome results
None listed