Aortic regurgitation
Conditions
Interventions
Sponsors
Union hospital tongji medical college huazhong university of science and technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The diagnosis of echocardiography was severe aortic insufficiency; 2. Age = 60 years; 3. Comply with AVR indications: 1) symptomatic AR; 2) No symptoms of heart failure+LVEF65mm or LVESD>50mm or LVESD/BSA>25mm/cm2; 4. According to the evaluation of the core laboratory, the anatomical structure of the aortic root is suitable for percutaneous TAVR; 5. Patients who are evaluated by two or more cardiovascular specialists as unsuitable or intolerant of surgery (any of the following): 1) STS score = 6%; 2). There are two or more serious irreversible major organ damage, such as heart disease, brain disease, lung disease, liver disease, kidney disease, blood coagulation disorder, malignant tumor, etc; 3). The patient is weak and cannot tolerate surgery; 4) Other surgical operation obstacles such as thoracic deformity, porcelain aorta, post bypass surgery, etc; 6. Patients who can understand the purpose of the study, voluntarily participate in and sign the informed consent form, and are willing to accept relevant examinations and clinical follow-up.
Exclusion criteria
Exclusion criteria: 1. Combined with other cardiovascular diseases requiring surgical operation at the same time, such as aortic dissection, coronary heart disease and three branch disease; 2. Complicated with moderate or above aortic stenosis; 3. Life expectancy<1 year; 4. Contraindication of antithrombotic therapy; 5. Arterial root anatomy and lesions are not suitable for artificial valve implantation; 6. Anatomical morphology or vascular diseases affecting the instrument approach; 7. Left ventricular thrombus; 8. Infectious endocarditis in the active period or other infections that the researcher thinks affect the operation; 9. The investigator judged that the patient or family members had poor compliance or refused (such as senile dementia) and could not complete the study as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composite end point of all cause mortality, stroke and heart failure related rehospitalization rate; | — |
Countries
China
Contacts
Public ContactNianguo Dong
Union hospital tongji medical college huazhong university of science and technology
Outcome results
None listed