Enhanced external counterpulsation promotes recovery of exercise-induced muscle damage(EIMD) via modulating metabolomic changes

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200057869

Enrollment

Unknown

Registered

2022-03-20

Start date

2022-03-20

Completion date

Unknown

Last updated

2023-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise-Induced Muscle Damage(EIMD)

Interventions

EECP:EECP (D/S>1.2, inflation pressure 0.035MPa-0.045Mpa)

Sham EECP :Sham EECP (inflation pressure 0.01Mpa)

Eligibility

Sex/Gender

Male

Age

25 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1.25-35 years old healthy men; 2.No history of smoking and alcoholism; 3.No history of taking drugs in the past 1 month; 4.BMI range: 20-23kg/cm2; 5.No history of trauma or surgery.

Exclusion criteria

Exclusion criteria: 1. Moderate to severe aortic valve insufficiency; 2. Dissecting aneurysm; 3. Significant pulmonary hypertension; 4. Various bleeding diseases or bleeding tendencies, or anticoagulants, INR>2.0; 5. Various heart valve diseases or congenital heart diseases with cardiac insufficiency; 6. Active phlebitis and venous thrombosis; 7. The limbs of counterpulsation are infected; 8. Uncontrolled hypertension (>170/110mmHg); 9. Uncontrolled arrhythmias, including frequent premature fluctuations; 10. Severe left heart failure; 11. Severe arterial occlusive disease of lower extremities.

Design outcomes

Primary

Measure	Time frame
Plasma targeted metabolome;PBMC (Peripheral blood mononuclear cells) mRNA;	—

Countries

China

Contacts

Public ContactGuifu Wu

Department of Cardiovascular Medicine, the Eighth Affiliated Hospital of Sun Yat-Sen University

wuguifu@mail.sysu.edu.cn+86 15989893111

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026