Effect of low carbohydrate diet on glucolipid metabolism in patients with type 2 diabetes mellitus

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200057832

Enrollment

Unknown

Registered

2022-03-18

Start date

2022-04-11

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus

Interventions

Low-carbohydrate diet group:Low-carbohydrate diet

Conventional diabetes diet group:Conventional diabetes diet

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Signed informed consent; 2. Type 2 diabetes diagnosed according to ADA standards (2013); 3. Age 18-65 at the time of selection, male or female; 4. Overweight and obese (BMI>24kg/m2), weight change less than 5kg in the last 3 months; 5. Be willing to follow dietary plans.

Exclusion criteria

Exclusion criteria: 1. Pregnant women, breastfeeding women or women planning a pregnancy in the trial period; 2. There are the following metabolic diseases: Type 1 diabetes, gestational diabetes, carnitine deficiency, carnitine palm acyltransferase (CPT) I or II deficiency, carnitine deficiency, fatty acid transferase II beta oxidation deficiency, the chain acyl dehydrogenase deficiency, long-chain acyl dehydrogenase deficiency, short chain dehydrogenase deficiency, long chain 3 - hydroxy fatty acyl coenzyme deficiency, in chains 3-hydroxyacyl-coenzyme deficiency, pyruvate carboxylase deficiency, porphyria, etc. 3. Have serious heart disease, myocardial infarction, unstable angina pectoris, chronic cardiac insufficiency; 4. Have definite liver disease, AST, ALT or total bilirubin higher than 2 times the normal upper limit; 5. chronic kidney disease, serum creatinine >135umol/L(>1.5mg/dL); 6. History of pancreatitis, active gallbladder disease, frequent gout, fat digestion disorder; 7. Acute and chronic inflammatory diseases, thyroid diseases, Cushing's syndrome, malignant tumors, and other patients; 8. There is a history of alcoholism or drug abuse, mental illness, or inability to comply with study procedures.

Design outcomes

Primary

Measure	Time frame
HbA1c;Diabetes drug dosage;	—

Secondary

Measure	Time frame
Fasting blood glucose;Fasting serum insulin;Triacylglycerol;Weight;Waist circumference;Homeostasis model of insulin HOMA-INDEX;	—

Countries

China

Contacts

Public ContactLinuo Zhou

Huashan Hospital Affiliated to Fudan University

Nally_zhou@163.com+86 13671822637

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026