Anti-N-methyl-D-aspartate receptor encephalitis
Conditions
Interventions
Gold Standard:CSF/serum positive for anti-NMDAR antibodies
Index test:EEG frequency domain analysis, machine learning models, brain networks
Sponsors
West China Second Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Case group: (1) In line with the diagnostic criteria for anti-NMDAR encephalitis in the "Clinical Diagnostic Criteria for Autoimmune Encephalitis" published in The Lancet Neurology in 2016: Six main clinical symptoms: 1) Abnormal behavior (mental behavior Abnormal) and/or cognitive dysfunction; 2) Language dysfunction manifested by decreased language, mute or nonstop speech; 3) Epileptic seizures; 4) Movement disorders; 5) Reduced level of consciousness; 6) Impaired autonomic function or central ventilation is insufficient. Presence of one or more of the six major clinical symptoms, with positive cerebrospinal fluid and/or serum anti-GluN1 antibodies, and exclusion of other diseases; (2) Under the age of 18; (3) Children who underwent EEG feature analysis had acute-phase EEG recordings; (4) Children who analyze the raw EEG data need to obtain at least one raw EEG data in the acute phase. 2. Control group: During the same period of hospitalization of children with anti-NMDAR encephalitis, patients with viral encephalitis with a clear pathogen: (1) With clinical manifestations of brain parenchyma damage, cerebrospinal fluid, and/or serum detection of clear virus antibody IgM, or viral nucleic acid; (2) Under the age of 18; (3) The results of laboratory examination of cerebrospinal fluid that meet the international diagnostic criteria for viral encephalitis; (4) Children with EEG characteristic analysis had acute phase EEG recordings; (5) Children undergoing EEG raw data analysis need to obtain at least one acute phase raw EEG data. 3. Normal control group: (1) Children without severe neurological chronic diseases or acute diseases were examined in the EEG room of our hospital; (2) Under the age of 18; (3) Age-matched with the case group, with a difference of 1-2 years; (4) Raw EEG data can be obtained. Relapse was defined as the onset of new symptoms during the convalescent period or the worsening of symptoms after 2 months of improvement or stabilization.
Exclusion criteria
Exclusion criteria: 1. Case group: (1) Children with anti-NMDAR encephalitis for whom clinical characteristic data could not be obtained; (2) Children suspected to be diagnosed with anti-NMDA receptor encephalitis, but not diagnosed children. 2. Control group: (1) Combined with other chronic diseases such as severe cardiopulmonary or metabolic diseases. 3. Normal group: (1) Children with suspected abnormal or abnormal EEG without neurological chronic disease or acute disease EEG examination; (2) Combined with other chronic diseases of the system such as severe cardiopulmonary or metabolic diseases. Others: The analysis of the original EEG data excludes EEG data with too much interference in the collection of EEG data and cannot remove the interference cases, or the extreme value is too large and does not conform to the common clinical EEG characteristics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| delta band;beta band;alpha band;theta band;gamma band; | — |
Countries
China
Contacts
Public ContactTao Yu
West China Second Hospital, Sichuan University
Outcome results
None listed