Heart failure
Conditions
Interventions
Observation group:Amiodarone + perindopril + spironolactone group (group I, n = 121)
Control group:Metoprolol succinate + perindopril + spironolactone group
Sponsors
People's Hospital of Chongqing Hechuan
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 55 to 75 years old; 2. Before admission, all patients used to take the Golden Triangle drug metoprolol succinate + perindopril + spironolactone regularly, and reached the maximum tolerated dose; 3. ECG indication at admission: rapid atrial fibrillation (heart rate > 100 BPM) and the duration of atrial fibrillation exceeds 7 days. After reaching dry weight, the average ventricular rate of ambulatory ECG is > 100 beats/min; 4. Metoprolol succinate should be temporarily stopped when the cardiac function grade of New York City reaches grade IV at admission; 5. Left ventricular ejection fraction (LVEF) 1200pg/ml; 6. All enrolled patients underwent esophageal ultrasound to confirm that there was no atrial thrombosis; 7. There was no ablation treatment plan for atrial fibrillation in recent 1 year.
Exclusion criteria
Exclusion criteria: 1. Valvular heart disease requiring surgical intervention; 2. Complicated with hyperthyroidism or diagnosed hyperthyroid heart disease; 3. There are contraindications to the use of oral amiodarone tablets; 4. Severe hepatic and renal insufficiency; 5. Severe indoor conduction block and complete left bundle branch block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular mortality;Rehospitalization rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| NT-proBNP;Left ventricular ejection fraction; | — |
Countries
China
Contacts
Public ContactYongrong Liu
People's Hospital of Chongqing Hechuan
Outcome results
None listed