Head and Neck Cancers
Conditions
Interventions
Experimental group:Nutritional Counseling plus Oral Nutritional Supplements (ONS)
Control group:Nutritional Counseling
Sponsors
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years old; 2. Newly diagnosed HNC and planned to undergo radiotherapy or newly diagnosed HNC with previous surgical treatment history and planned to undergo radiotherapy; 3. KPS score >= 70 or ECOG score =4*10^9/L, ANC>=1.5*10^9/L, HGB>=9g/L, PLT>=100*10^9/L; 9. Blood biochemical outcomes: normal liver function (or TBIL, AST, ALT = ml/min or CRE <=1.5 times the upper limit of normal value).
Exclusion criteria
Exclusion criteria: 1. Has other malignancy; 2. Severe digestive system diseases; 3. Severe heart, lung, liver and kidney function insufficiency; 4. Currently undergoing other forms of nutritional treatment; 5. Refuse to use ONS; 6. Vulnerable groups, including mental illness patients, cognitively impaired patients, critically ill patients, minors, pregnant women, and etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Weight Change;Body Mass Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Toxicity Criteria of the Radiation Therapy Oncology Group;Quality of Life Score;PG-SGA (Patient-generated subjective nutrition assessment) Score;Handgrip Strength;Skinfold Thickness;Fat Free Mass Index;L3-CT Skeletal Muscle Index;Plasma Protein Levels;T Lymphocyte Subpopulations Analysis ;Adverse Effects/Events;Response Rate;1 or 2 Years Survival Rate;Progression-free survival;Overall Survival; | — |
Countries
China
Contacts
Public ContactSun Xiaonan
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed