Acute ischemic stroke/transient ischemic attack
Conditions
Interventions
Group 1:moderate intensity statins with ezetimibe
Group 2:high intensity statins
Sponsors
The Fifth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years. 2. In the acute period of ischemic stroke, that is, within 1 week after the onset of mild ischemic stroke (NIHSS score =16 points), and within 2 weeks after the onset of other TIA patients and within 1 week after the onset of TIA patients. 3. Patients or family members sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating patients; 2. Cardiogenic TIA or stroke; 3. Ischemic cerebrovascular diseases caused by vascular malformations, tumors, abscesses, revascularization surgeries or trauma and other non-atherosclerotic diseases; 4. Intracranial hemorrhage; 5. Known allergy to statins or ezetimibe; 6. Active liver disease or liver dysfunction, defined as >=2 times the upper limit of normal (ULN) for aspartate aminotransferase (AST) or alanine aminotransferase (ALT); 7. Blood diseases that may lead to thrombosis; 8. Endarterectomy was performed within 1 month; 9. Severe renal insufficiency or nephrotic syndrome; 10. Serum creatine kinase >=5 times the upper limit of normal (ULN); 11. Participate in another clinical study within 30 days; 12. Any disease or abnormality that the investigator believes may endanger the patient's safety during the study period; 13. Patients who have used any medication known to affect lipid levels or immunosuppressants, azole antifungals or drugs that can cause rhabdomyolysis when used in combination with statins within the last 1 month, or probucol within 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Low density lipoprotein cholesterol levels meet the standard rate; | — |
Countries
China
Contacts
Public ContactZhang Lei
The Fifth Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed