Acute ischemic stroke (AIS)
Conditions
Interventions
Intensive BP lowering group:For the intensive management group, the target SBP range is <130 mmHg. Antihypertensive treatment will be initiated in patients randomized to this group as soon as possible
Conventional BP lowering group:For the standard management group, the target SBP range is <180 mmHg. Antihypertensive treatment will only be deemed compulsory when SBP exceeds 180 mmHg. If SBP reaches
Sponsors
Sichuan University, West China Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. Clinical diagnosis as AIS induced by occlusion of large vessels of anterior circulation (including ICA, the M1/M2/M3 segment of the MCA or the A1/A2 segment of ACA) confirmed by digital subtraction angiography (DSA), without occlusion of posterior circulation; 3. EVT within 6 hours from onset (time from onset to puncture =2b) after EVT; 5. Postoperative BP >130mmHg occurs within 6 hours after then end of thrombectomy; 6. Written informed consent (or signed by proxy).
Exclusion criteria
Exclusion criteria: Participants who meet one or more of the following criteria will be excluded: 1. ASPECTS value =70% or even occlusion in ipsilateral or contra-lateral, intracranial or extracranial large arteries after EVT; 8. Pre-stroke mRS>=2: 9. Occurrence of ICH, cerebral hernia, END or other outcome events before randomization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of adverse outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intracranial hemorrhage ;Brain oedema;Early neurological dererioration;all cause death within 7 days after randomization or until discharge; | — |
Countries
China
Contacts
Public ContactWu Bo
West China Hospital, Sichuan University
Outcome results
None listed