cervical cancer
Conditions
Interventions
Group 1:neoadjuvant chemotherapy followed by surgery
Group 2:abdominal radical hysterectomy + pelvic lymphadenectomy ± para-aortic lymphadenectomy
Sponsors
The First People's Hospital of Kashgar
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Uygur women aged 18-65 years; 2. Newly treated patients with cervical cancer; 3. Clinical diagnosis of cervical cancer stage IB3 or IIA2 (FIGO stage, 2018); 4. MRI examination confirmed no distant metastasis, no obvious bladder and rectal invasion; 5. Pathological diagnosis of cervical squamous cell carcinoma, adenocarcinoma or adenocarcinoma; 6. Expected survival of more than 3 months; 7. PS score 0-1.
Exclusion criteria
Exclusion criteria: 1. Patients with other malignant tumors; 2. MRI indicated that the short diameter of pelvic and abdominal lymph nodes was greater than 10mm; 3. Patients with a history of myocardial infarction or stroke, or unstable angina, decompensated heart failure, or deep vein thrombosis; 4. Liver insufficiency (aspartate/alanine aminotransferase >2.5 times the upper limit of the standard); 5. Renal insufficiency (serum muscle liver >2 times the standard upper limit); 6. A history of chronic lung disease with restrictive respiratory dysfunction; 7. History of transplantation of important organs and immune diseases; 8. History of severe mental illness and brain dysfunction; 9. A history of drug abuse or use; 10. Unable or unwilling to sign informed consent or comply with study requirements; 11. Patients during pregnancy and perinatal period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;the need for adjuvant radiotherapy;economic benefit ratio;incidence of recent adverse reactions;incidence of long-term side effects;quality of life; | — |
Countries
China
Contacts
Public ContactWan Yingxiang
The First People's Hospital of Kashgar
Outcome results
None listed