gynecological laparoscopic surgery
Conditions
Interventions
1:After induction, 0.25mg/kg of esmketamine was injected intravenously, and then 0.15mg/kg/h of esmketamine was continuously injected by pump during operation
2:After induction, 50mg/kg of magnesium sulfate was injected intravenously, and then 8mg/kg/h of magnesium sulfate was continuously injected by pump during operation
3:After induction, 0.15mg/kg esketamine and 25mg/kg of magnesium sulfate was injected intravenously, then 0.075 mg/kg/h esketamine and 4mg/kg/h of magnesium sulfate was continuously injected by pump d
4:After induction,the same amount of normal saline was injected intravenously, and then the same amount of normal saline was continuously injected by pump during operation
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients who intend to undergo gynecological laparoscopic surgery; 2.Age 18-65 years old; 3.BMI 18.5-28 kg/m2 4.ASA grade I~III; 5.The anaesthesia informed consent can be signed.
Exclusion criteria
Exclusion criteria: 1.Patients allergic to narcotic drugs used; 2.Patients with abnormal liver and kidney function before operation; 3.Patients with long-term use of opioids; 4.Patients receiving long-term treatment with calcium channel blockers or magnesium; 5.Patients with atrioventricular conduction disorder; 6.Patients with mental and intellectual abnormalities or inability to communicate normally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS;Hydromorphone consumption of PCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| scale scores of QoR-15;scale scores of QoR-15;Postoperative intestinal function recovery time;chronic pain;adverse reactions;Hemodynamic changes; | — |
Countries
China
Contacts
Public ContactAi Yanqiu
Outcome results
None listed