Heart valve disease
Conditions
Interventions
observation group:Complete preservation of mitral valve leaflets
control group:mitral valve leaflet resection
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Age = 18 years old, gender is not limited; 2.A clear diagnosis of primary mitral regurgitation was made by cardiac ultrasound, electrocardiogram and other related examinations: (2014 AHA/ACC guidelines: moderate or above regurgitation, or regurgitation flow per beat = 30ml, or reverse Flow fraction = 30%, or regurgitation port area = 0.2 cm2, when multiple indicators are inconsistent, the more serious one shall prevail); 3.Evaluation of the mitral valve after intraoperative cardiac arrest and left atrial incision to verify that both leaflet resection and leaflet preservation strategies are feasible; 4.The patient himself agrees to participate in this clinical study and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Aortic valve surgery is planned at the same time; 2. Significant left ventricular dysfunction (LVEF<40%); 3. Moderate aortic regurgitation, severe mitral valve annular calcification; 4. Spinal deformity, thoracic deformity, severe thoracic adhesion; 5. Taking other experimental drugs or participating in other clinical studies within 1 month before being enrolled in the study; 6. The researcher believes that it is not suitable to participate in this clinical researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mitral valve opening area;Mitral valve mean transvalvular gradient;Mitral valve gradient at peak motion and at rest; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6 minutes walking distance; | — |
Countries
China
Contacts
Public ContactZhou Yang
Leshan People's Hospital
Outcome results
None listed