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Effect of subhypnotic dose of propofol combined with tropisetron on nausea and vomiting in patients with postoperative intravenous analgesia after gynecology

Effect of subhypnotic dose of propofol combined with tropisetron on nausea and vomiting in patients with postoperative intravenous analgesia after gynecology

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200057639
Enrollment
Unknown
Registered
2022-03-15
Start date
2022-03-13
Completion date
Unknown
Last updated
2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nausea and vomit

Interventions

experimental group:Tropisetron and propofol

Sponsors

People's Hospital of Three Gorges University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Gynecological surgery and postoperative intravenous analgesia; 2. Age: 18-64 years old; 3. ASA classification: I-II; 4. Body Mass index (BMI): 18-24 kg/m2; 5. Preoperative examination of heart, lung, liver and kidney function were normal; 6. Have the ability of independent behavior, clear consciousness and understand the investigation content; 7. Volunteers to participate in the study and sign the agreement.

Exclusion criteria

Exclusion criteria: 1. Patients with hypertension, heart disease, diabetes and other important systemic diseases with unsatisfactory control; 2. Long-term dependence on analgesics and other drugs; 3. History of allergy to propofol, toanisagar and other drugs; 4. A history of migraines; 5. Severe hyperlipidemia.

Design outcomes

Primary

MeasureTime frame
nausea rating;vomiting degree score;sedation scores;times of rescue;

Secondary

MeasureTime frame
satisfaction; based blood pressure;based heart rate;oxyhemoglobin saturation;

Countries

China

Contacts

Public ContactZhaojun Qin

People's Hospital of Three Gorges University

qin1172001@aliyun.com+86 15871619516

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026