MDD
Conditions
Interventions
Group 1 :pgACC FC-guided iTBS
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for depression in the International Classification of Diseases DSM-V, and be diagnosed with depression; 2. HAMD-17 > 18 points (Melzeretal.,2012); Mood Disorder Questionnaire < 7 points; 3. The current depressive episode was confirmed by the questionnaire of Emotional Disorders and schizophrenia in school-age children, KidDI-SADS Lifetime Edition (K-SADS-PL); 4. No gender limitation, age 12-18 years, right-handed, ethnic Han; 5. Subjects who are able to understand and willing to strictly follow the clinical trial protocol to complete the study, have informed consent from the guardian and can sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Contraindicated patients with MRI and TMS; 2. Severe heart, liver and kidney diseases, no thyroid, tumor, blood history, rheumatism, malnutrition and nervous system diseases; 3. Patients previously treated with rTMS or ECT; 4. Schizophrenia, bipolar disorder, history of abuse of tobacco, alcohol and other psychoactive substances; 5. People at high risk of suicide; 6. The patient is a pregnant or lactating woman or planning to become pregnant; 7. No immunomodulators and hormone preparations for at least half a year, no antipyretic and analgesic drugs for 2 weeks; 8. Those considered unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale, HAMA;Snaith-Hamilton Pleasure Scale, SHAPS;Digital symbol substitution test, DSST;Digital span test, DST;Theamplitudeof low-frequency fluctuations, ALFF;Functional connection, FC; | — |
Countries
China
Contacts
Public ContactZang Yufeng
Hangzhou Normal University
Outcome results
None listed