hepatocellular carcinoma
Conditions
Interventions
Group 1 :Renvatinib
Group 2:Renvatinib + Arsenic Trioxide
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Regardless of gender, age >= 18 years; 2. Histological and cytological specimens were obtained and confirmed as primary hepatocellular carcinoma. Or meet the clinical diagnostic criteria in the "Norms for Primary Liver Cancer Diagnosis and Treatment 2019 Edition" issued by the Ministry of Health of China, and be diagnosed with primary liver cancer; 3. Pre-survival time >= 12 weeks; 4. Within 1 week prior to selection, the laboratory examination must meet the following conditions: (1) Neutrophil-leukocyte count (ANC) >= 1.5 x 10^9/L; (2) Platelet (BPC) >= 75 x 10^9/L; (3) Hemoglobin (Hgb) >= 80 g/L; (4) Alanine aminotransferase and aspartate aminotransferase (ALT and AST) = 50 mL/min); (7) No obvious abnormality in electrocardiogram; 5. General Condition Score (ECOG): 0,1 or 2; 6. No systemic therapy was received before enrollment, including systemic chemotherapy (oxaliplatin based chemotherapy) or targeted therapy (such as sorafenib).
Exclusion criteria
Exclusion criteria: 1. Receiving other anti-tumor treatments; 2. Severely infected or known to be infected with HIV; 3. Allergic to arsenic-containing drugs; 4. Known central nervous system tumors include metastatic brain diseases; 5. Severe renal insufficiency (serum creatinine > 200 ummol/L) or other serious organ diseases; 6. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;objective response rate;Serum drug resistance associated protein;Evaluation method of liver cancer related symptoms;Quality of life evaluation;Blood routine;liver function;coagulation function;urine and fecal routine;angiogenesis inhibitor;inflammatory factor;tumor markers; | — |
Countries
China
Contacts
Public ContactXiaofeng Zhai
Shanghai Changhai Hospital
Outcome results
None listed