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Efficacy of Vonolase-based dual therapy in the treatment of Helicobacter pylori: a randomized, open study

Efficacy of Vonolase-based dual therapy in the treatment of Helicobacter pylori: a randomized, open study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200057625
Enrollment
Unknown
Registered
2022-03-15
Start date
2022-03-07
Completion date
Unknown
Last updated
2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori infection

Interventions

Group 1 :taking dual therapy continuously for 10 days
Group 2:taking dual therapy continuously for 14 days

Sponsors

Department of Gastroenterology, Peking University Third Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients over 18 years; 2. UBT should be positive, and the eradication therapy is needed by the opnion of doctor; 3. The informed consent is signed.

Exclusion criteria

Exclusion criteria: 1. Suffering from Zuo-AI syndrome or excessive gastric acid secretion; 2. Previous Hp eradication treatment; 3. Has undergone major surgery or plans to undergo surgery that may affect gastric acid secretion within 30 days prior to the screening visit, or is not suitable for medication for other reasons; 4. Received antibiotics, bismuth, acid suppressive drugs within 4 weeks; 5. History of hypersensitivity or allergy to vonorazine or amoxicillin; 6. Being treated with azanavir or ripiavirin; 7. Abnormal liver and kidney function; 8. Female subjects are pregnant or lactating; 9. Having other serious medical conditions; 10. A history of alcohol abuse, illicit drug use or drug addiction in the 12 months prior to screening; 11. You need to take prohibited drugs; 12. Subjects were participating in another clinical study at the time of enrollment in this study; 13. History of malignancy; 14. Has a known acquired immune deficiency syndrome.

Design outcomes

Primary

MeasureTime frame
urea breath test;

Countries

China

Contacts

Public ContactZhou Liya

Peking University Third Hospital

liyazhou@medmail.com.cn+86 15611908239

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026