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Sequential method for determining the maximum dose of cisatracurium continuously infused for intraoperative motor evoked potentials monitoring in intramedullary spinal cord tumor surgery

Sequential method for determining the maximum dose of cisatracurium continuously infused for intraoperative motor evoked potentials monitoring in intramedullary spinal cord tumor surgery

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200057610
Enrollment
Unknown
Registered
2022-03-15
Start date
2022-02-28
Completion date
Unknown
Last updated
2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intramedullary spinal cord tumor

Interventions

experimental group:continuously infuse cisatracurium

Sponsors

Beijing Tsinghua Changgung Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Intramedullary spinal cord tumor resection under general anesthesia and TceMEP monitoring are planned to be performed in our hospital at an selected time; 2. Aged between 18 and 65 years, regardless of gender; 3. ASA grade: I-II; 4. Voluntarily participate in clinical trials and sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with severe heart disease, respiratory dysfunction, and abnormal liver and kidney function; 2. Patients complicated with severe neuromuscular diseases before surgery; 3. Patients who already had severe limb movement disorder before surgery (muscle strength grade 3 and below); 4. Continuous loss of MEP signal during operation due to other reasons or clear new limb movement disorders found in postoperative follow-up; 5. Patients with previous allergy to cis-atracurium were identified; 6. Patients with a history of epilepsy, cardiac pacemaker installation, intracranial metal implant or skull fracture and other motor evoked potential contraindications; 7. The surgeon or researcher considers it unsuitable to participate in the study; 8. Continued treatment in ICU after surgery; 9. The patient cannot understand or cooperate with the study and refuses to participate in the study.

Design outcomes

Primary

MeasureTime frame
Whether motor evoked potentials can be successfully monitored;

Countries

China

Contacts

Public ContactHuan Zhang

Beijing Tsinghua Changgung Hospital

hzba03013@btch.edu.cn+86 13611326452

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 7, 2026