Research of target accurate localization of Parkinson's disease stereotactic surgery based on quantitative susceptibility mapping

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200057582

Enrollment

Unknown

Registered

2022-03-15

Start date

2022-03-01

Completion date

Unknown

Last updated

2023-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

STN experimental group:QSM based targeting

STN control group:Conventional targeting

GPi experimental group:QSM based targeting

GPi control group:Conventional targeting

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Those who meet the diagnostic criteria of primary Parkinson's disease; 2. Patients who plan to undergo DBS surgery with subthalamic nucleus (STN) and internal globus pallidus (GPi) as surgical targets; 3. Those who can cooperate to complete MRI T1, T2 and SWI sequence scanning; 4. There is no contraindication of neurosurgery and the informed consent is signed; 5. Those who can complete at least one follow-up within 1 year after operation.

Exclusion criteria

Exclusion criteria: 1. Those who have metal implants or cannot complete long-term MRI scanning due to physiological and psychological reasons; 2. Contraindications to surgery; 3. Those who lost follow-up after operation.

Design outcomes

Primary

Measure	Time frame
Target coordinate;Coordinate inter-observer consistency;Border of nucleus;	—

Secondary

Measure	Time frame
Unified Parkinson's Disease Rating Scale, UPDRS score;	—

Countries

China

Contacts

Public ContactZhiwei Ren

Xuanwu Hospital, Capital Medical University

rzw@xwhosp.org+86 010-83198882

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026