heart valve disease
Conditions
Interventions
Test group:Bifidobacterium animalis
Control group:Placebo
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Preoperative cardiac color Doppler ultrasonography was diagnosed as simple heart valve disease, and the patients were treated with valve replacement or plastic surgery under cardiopulmonary bypass. The diagnosis and surgical indications of valvular heart disease are based on the "Clinical Diagnosis and Treatment Guidelines for Cardiovascular Surgery" (2011 edition) compiled by the Chinese Medical Association; 2. The age is 18-70 years old, male and female are not limited; 3. Not complicated with severe heart, lung, kidney, liver dysfunction and metabolic diseases; 4. Patients and their family members understand the situation of this experiment and agree to participate in all terms of this research, sign the informed consent form approved by the ethics committee, agree to accept the current treatment plan, and be able to cooperate with the experiment.
Exclusion criteria
Exclusion criteria: 1. Patients who cannot take orally or absorb gastrointestinal drugs; 2. Those who participated in other clinical trials on probiotics within 30 days before enrollment; 3. Those who have undergone cardiovascular surgery or patients who need to undergo other cardiac surgery at the same time; 4. Pregnant and lactating women; 5. Those who have a history of allergies to experimental drugs or similar drugs, allergic constitution or are currently suffering from allergic diseases; 6. Patients with severe neurological and psychiatric diseases; 7. Those with autoimmune diseases, immunodeficiency diseases, or a history of organ transplantation; 8. Patients with severe heart, lung, kidney, liver dysfunction and metabolic diseases; 9. Patients who are considered unsuitable for inclusion in this study by the investigator.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| White blood cell count;Cardiac Function;Liver function;Kidney function; | — |
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal symptom score;Stool high-throughput sequencing; | — |
Countries
China
Contacts
Public ContactTang Yanhua
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed