postoperative delirium
Conditions
Interventions
Experimental group:maintain SBP within ±10% of baseline
Control group:Patients will receive vasopressors in case of a drop in SBP below 90 mmHg or lower than 30% from the baseline
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >=60 years; 2. ASA physical status II to III; 3. Patients with a history of hypertension; 4. Patients scheduled for major noncardiac surgery expected to last at least 2h under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients with preexisting cognitive impairment; 2. Patients with severe neurologic conditions; 3. Patients with a major psychiatric condition such as bipolar disorder, major depression, schizophrenia, or dementia; 4. Patients with liver dysfunction (Child-Pugh grade C),renal failure,acute coronary syndrome,severe cardiac arrhythmias,acute or decompensated heart failure; 5. Patients with severely impaired visual, auditory or verbal communication; 6. Patients with a history of psychotropic substance abuse; 7. Patients with secondary hypertension; 8. Patients with severe uncontrolled hypertension(systolic blood pressure>=180mmHg or diastolic blood pressure>=110 mm Hg).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| delirium duration and severity;postoperative duration of hospitalization;all-cause mortality;non-delirium complications;postoperative cognitive function;NRS pain scores both at rest and with movement; | — |
Countries
China
Contacts
Public ContactSu Liu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed