Blood tumors requiring long-term chemotherapy
Conditions
Interventions
experimental group:The drug-containing coating was inserted and a central venous catheter was inserted
control group:Put in a peripheral central venous catheter
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. The patient aged >=18 years and needed PICC insertion, regardless of gender; 2. Physical condition score ECOG=3 months; 4. No malignant tumors of other organ entities were present in diagnosis; 5. Patients with first catheterization or target vein more than 1 year since the last PICC extraction, and no other vascular access devices were indwelled; 6. Patients are willing and able to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient had thrombosis in the superior vena cava or vena cava; 2. The patient had allergic history of chlorhexidine; 3. Patients with peripheral or central vein stenosis (catheter area/target vein area >45%); 4. Superior vena cava syndrome was diagnosed; 5. Vascular occlusion or severe lesions at the puncture catheterization site of the patient; 6. Pregnant or lactating patients; 7. Patients are not willing to use contraception as required during clinical trials; 8. Coagulopathy (INR > 2 or aPTT> 66, bleeding and bleeding tendency); 9. Alcoholics or drug addicts, drug abusers; 10. Skin conditions such as inflammation, rash, scabs, drainage, hematoma, phlebitis, or extravasation or exudation of intravenous fluids within 15cm or less from the proposed catheter insertion site; 11. The patient is mentally incapable or unable to understand the requirements of participating in the study; 12. The patient's co-existing diseases limited her participation in the study, and she could not comply with the follow-up or affected the scientific and integrity of the study; 13. Circumstances that are not suitable for participation in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of first attempt insertion success;The Incidence of catheter-related bloodstream infection ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of complete loss of catheter function;Incidence of catheter-associated external wall thrombosis;Device performance evaluation;Evaluation of other safety parameters; | — |
Countries
China
Contacts
Public ContactXu Jia
Teleflex Medical Trading Shanghai Company Limited
Outcome results
None listed