Epidural related maternal fever
Conditions
Interventions
Butorphanol group:30 minutes after epidural labor analgesia, intravenous butorphanol 1ml (1mg/ml) was administered
Control group:30 minutes after epidural analgesia, 1ml of normal saline was given intravenously
Sponsors
Women' Hosipital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital)
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Classification I-II; 2. Aged 18-40 years; 3. BMI =37 weeks; 5. Parturient parturient with head; 6. Epidural analgesia and dilation of uterine orifice <=3cm; 7. Initial body temperature is normal; 8. No contraindications to epidural anesthesia, no pregnancy-related diseases such as gestational hypertension and gestational diabetes, no infectious diseases (such as hepatitis B and syphilis), no abnormal monitoring of fetal heart rate before labor analgesia (fetal heart rate range 110-160 bpm).
Exclusion criteria
Exclusion criteria: 1. Premature rupture of membranes; 2. Contraindications to intraspinal anesthesia (e.g., abnormal coagulation function, puncture site infection); 3. Those who have known the ingredients of the study drugs or are allergic to other drugs used in the study; 4. Use opioids and other sedative and analgesic drugs, magnesium sulfate, antipyretic and analgesic drugs within one week; 5. Patients with a history of drug abuse; 6. Patients with sleep apnea syndrome; 7. Patients with severe heart, lung, liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrapartum fever rate (T>=37.5?);Determination of cytokines in HUVECs and TBS cells;Determination of cytokines in HUVECs and TBS cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal temperature;The consumption of ropivacaine hourly;The consumption of opioid drugs;Total comsumption of ropivacaine;Total comsumption of opioid drugs;Duration of rupture;Method of rupture;Number of vaginal examinations;Total comsumption of oxytocin;First duration of labor;Second duration of labor;Third duration of labor;Total duration of labor;Incidence of cesarean section;Incidence of instrumental delivery;Bleeding volume;Incidence of fetal arrhythmia;Neonatal Apgar score (1min);Neonatal Apgar score (5min);Neonatal NICU conversion rate;Incidence of butorphanol related adverse reactions (nausea and vomiting);Serum inflammatory factor concentration; | — |
Countries
China
Contacts
Public ContactLi Caijuan
Women' Hosipital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital)
Outcome results
None listed