autism spectrum disorder
Conditions
Interventions
Control:placebo
Experimental ?:probiotics(CFU=3x10^10/day)
Experimental ?:probiotics(CFU=1x10^11/day)
Sponsors
Jinan Central Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of ASD according to criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5); 2. Age 3–10 years; 3. History of chronic constipation, subjects reported an average of = 3 spontaneous bowel movements per week for at least 3 months prior to screening visits.
Exclusion criteria
Exclusion criteria: 1. Schizophrenia, other psychosis, and mood disorders, including bipolar disorder and major depressive disorder according to the DSM-V criteria; 2. Seizure attack in the past year; 3. History of severe head trauma or stroke; 4. Suffering from serious infectious diseases or infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autism Behavior Checklist;Oral/Gut Microbiota;Metabonomics;Gastrointestinal Symptoms;Cytokine; | — |
Countries
China
Contacts
Public ContactHuajun Zheng
Shanghai Institutue for Biomedical and Pharmaceutical Technologies
Outcome results
None listed