The mechanism of TGF-ß1-induced TRPV1 sensitization in myocardial ischemia-reperfusion injury

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200057444

Enrollment

Unknown

Registered

2022-03-12

Start date

2023-01-01

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Ischemia Reperfusion Injury

Interventions

Gold Standard:In this study, the changes of serum troponin and TGFß1 in perioperative blood samples of patients undergoing cardiac valve replacement surgery were observed to investigate the role of TG

Index test:The expression levels of TGFß1 and troponin in blood samples were monitored by ELISA.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.From January 1, 2023 to June 30, 2023, patients were admitted to our hospital and planned to receive double valve replacement under cardiopulmonary bypass.

Exclusion criteria

Exclusion criteria: 1. Abnormal coagulation function before operation; 2. Severe heart failure, New York Heart Function Rating VI; 3. There is cancer, endocrine system or immune system disease.

Design outcomes

Secondary

Measure	Time frame
Troponin;	—

Primary

Measure	Time frame
TGFß1;	—

Countries

China

Contacts

Public ContactZhenxiao Ma

The first affiliated hospital of USTC Anhui provincial hospital

ma_zhenxiao@163.com+86 18255386986

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026