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Comparison of different priming solutions for continuous venovenous hemofiltration with regional citrate anticoagulation

Comparison of different priming solutions for continuous venovenous hemofiltration with regional citrate anticoagulation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200057383
Enrollment
Unknown
Registered
2022-03-10
Start date
2017-10-01
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CRRT treatment techniques

Interventions

the citrate group:a sodium citrate solution (physiological sodium chloride 970 ml + 4% sodium citrate 30 ml) was used to prime the circuit,
the heparin group:a heparin solution (heparin 25 mg in physiological sodium chloride 1000 ml, Baxter, Deerfield, IL, USA) was used to prime the circuit before CVVH was performed
the saline group:he pipeline was primed first with heparin saline (heparin 25 mg in physiological sodium chloride 1000 ml, Baxter, Deerfield, IL, USA) and then with 250 ml of saline before CVVH was pe

Sponsors

The Second Affiliated Hospital of Hainan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. ARF patients who need CRRT or CRF and maintenance hemodialysis patients; 2. Accompanied by one of the following conditions: 1) Acute pulmonary edema; 2) Hemodynamic instability; 3) Renal edema; 4) Hydrothorax and ascites.

Exclusion criteria

Exclusion criteria: 1.2, activated partial thromboplastin time (APTT)>60 seconds, or bleeding within 24 hours.

Design outcomes

Primary

MeasureTime frame
the coagulation function;platelets;The coagulation degree of the filters;

Secondary

MeasureTime frame
electron microscopy;The citrate dosage;the decrease in serum creatinine;the decrease in blood urea nitrogen;

Countries

China

Contacts

Public ContactHuiling Gan

Xiangya Hospital of Central South University

496656930@qq.com+86 13647572456

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026