acute kidney disease and renal dysfunction
Conditions
Interventions
exposure group:using PPIs
control gruop:without PPIs
Sponsors
The Third Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnose as non-small cell lung cancer stage III-IV; 2. Treatment with PD-1 inhibitors; 3. Age between 18-65 years old; 4. Voluntarily participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Autoimmune diseases, such as systemic lupus erythematosus, Sjogren's syndrome, vasculitis, etc; 2. Basic renal disease (abnormal urine detection, such as urine protein or urine occult blood, or estimated glomerular filtration rate<60ml/min/1.73m2; 3. History of major allograft organ transplantation, especially kidney transplantation; 4. For gastrointestinal diseases, proton pump inhibitors must be used for a long time; 5. Have a history of heart failure, angina, severe arrhythmia or pericardial disease; 6. Infectious diseases, including active hepatitis B or C, syphilis, acquired immunodeficiency syndrome (AIDS); 7. Serious infectious diseases; 8. The expected survival time is less than half a year; 9. Mental disorders, including clinically defined depression and schizophrenia; 10. Any other situation that may limit the patient's ability to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AKD: kidney injury within 3 months, including AKI; | — |
Countries
China
Contacts
Public ContactMin Yang
The Third Affiliated Hospital of Soochow University, Changzhou 213003
Outcome results
None listed