MDD
Conditions
Interventions
Sponsors
The first hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet DSM-V diagnostic criteria for depression and are diagnosed with severe depressive episode; 2. HAMD>17 points (Melzer et al., 2012); Chinese version of Mood Disorder Questionnaire (MDQ)<7 points; 3. Concise International Psychiatric Interview 7.0.0 (M.I.N.I.7.0.0) was used to confirm that the subject was currently suffering from depression; 4. Gender unlimited, age 20-55; 5. Subjects who can understand and are willing to strictly abide by the clinical trial protocol to complete the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Magnetic resonance and TMS contraindications; 2. Serious heart, liver and kidney diseases, no thyroid, tumor, blood history, rheumatism, malnutrition, nervous system and other diseases; 3. Schizophrenia, bipolar disorder, history of abuse of tobacco, alcohol and other psychoactive substances; 4. High risk of suicide; 5. The patient is a pregnant or lactating woman or a planned pregnancy; 6. Not taking immunomodulator and hormone preparations for at least half a year, and not taking antipyretic and analgesic drugs for 2 weeks; 7. The researcher thinks it is not suitable to be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale,HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale,HAMA;Self-rating depression scale,SDS;Self-rating anxiety scale,SAS;The Insomnia Severity index,ISI;Beck Scale for Suicide Ideation-Chinese Version, BSI-CV;Visual Analogue Score, VAS;Clinical Global Impression, CGI;Snaith-Hamilton Pleasure Scale, SHAPS; | — |
Countries
China
Contacts
Public ContactWang Yumei
Hebei Provincial People's Hospital
Outcome results
None listed