Effects of subdose esketamine combined with transverse abdominis plane block on laparoscopic hand hemodynamics and postoperative pain

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200057352

Enrollment

Unknown

Registered

2022-03-09

Start date

2022-03-01

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecologic laparoscopic surgery

Interventions

Experimental group:Esketamine

Control group:Physiological saline

Eligibility

Sex/Gender

Female

Age

60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. 60 to 85 years; 2. Gynecological laparoscopic surgery under selective general anesthesia; 3. Body mass index 18-30 kg/m2; 4. ASA sizing I - III.

Exclusion criteria

Exclusion criteria: 1. Have coronary heart disease, myocardial infarction, cerebral infarction and other cardiovascular diseases; 2. Mental illness; 3. Endocrine and metabolic diseases such as diabetes and adrenal cortex dysfunction; 4. Hyperthyroidism; 5. Complicated with central nervous system and mental diseases; 6. Esketamine and opioid allergy; 7. Local anesthetic allergy; 8. Recently taking psychotropic drugs or analgesics; 9. Being involved in other clinical trials.

Design outcomes

Primary

Measure	Time frame
Blood pressure;	—

Secondary

Measure	Time frame
pain;Nausea and vomiting;Extubation time;Postoperative psychiatric reaction;complications;	—

Countries

China

Contacts

Public ContactZuo Zhenyan

Changzhou Second People's Hospital

1035856811@qq.com+86 18944455052

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026