Combining intracranial pressure via a lumbar catheter and cerebrospinal fluid biomarker provide prognostic predictive performance for neurologic outcomes in cardiac arrest survivors

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200057314

Enrollment

Unknown

Registered

2022-03-08

Start date

2021-07-01

Completion date

Unknown

Last updated

2023-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac arrest

Interventions

None listed

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age> eighteen years old; 2. Cardiac arrest survivors inside or outside the hospital; 3. GCS measured immediately after ROSC<= 8.

Exclusion criteria

Exclusion criteria: 1. Traumatic or intracranial hemorrhage CA; 2. Ineligible for lumbar puncture (LP) (brain computed tomography showed severe cerebral edema, or coagulopathy (platelet count 1.5)); 3. Patients with end-stage tumors; 4. The time admitted to ICU is more than 24 hours after ROSC.

Design outcomes

Primary

Measure	Time frame
Glasgow Pittsburgh Cerebral Performance Category scale;Modified Rankin Scale;	—

Secondary

Measure	Time frame
intracranial pressure;serum and CSF lactate level;serum and CSF lactate dehydrogense level;CSF-serum albumin quotient;serum and CSF pyruvate level;serum and CSF S-100B level;serum and CSF co-peptin level;serum and CSF NSE level;serum and CSF Secretoneurin level;serum and CSF Glial-Fibrillary Acidic Protein (GFAP) level;serum and CSF UbiquitinC-terminal hydrolase L1 (UCH-L1) level;serum and CSF Neurofilaments-L (NF-L) level;	—

Measure

Time frame

intracranial pressure;serum and CSF lactate level;serum and CSF lactate dehydrogense level;CSF-serum albumin quotient;serum and CSF pyruvate level;serum and CSF S-100B level;serum and CSF co-peptin level;serum and CSF NSE level;serum and CSF Secretoneurin level;serum and CSF Glial-Fibrillary Acidic Protein (GFAP) level;serum and CSF UbiquitinC-terminal hydrolase L1 (UCH-L1) level;serum and CSF Neurofilaments-L (NF-L) level;

—

Countries

China

Contacts

Public ContactLijun Liu

Second Affiliated Hospital of Soochow University

liulijun@suda.edu.cn+86 13962192756

Outcome results