Bowel Preparation
Conditions
Interventions
3L PEG+L group:add Linaclotide
Sponsors
The Affiliated People’s Hospital of Ningbo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The diagnostic criteria for chronic constipation according to the Rome IV criteria: 1) must include two or more of the following: >25% of evacuations are labored; >25% of evacuations are dry bulbous or hard; >25% of evacuations are incomplete; >25% of evacuations have anorectal obstruction (or blockage); >25% of evacuations require manual assistance; spontaneous evacuations <3 times per week. 2) rare occurrence of dilute feces when laxatives are not used 3) Does not meet the diagnostic criteria for IBS. All functional gastrointestinal disorders must meet the symptom requirement for at least 6 months prior to diagnosis and within the last 3 months.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of allergy to this study drug. 2) Patients with coexisting severe heart, liver, or kidney disease that cannot tolerate colonoscopy 3) Patients with coexisting intestinal obstruction, intestinal perforation and electrolyte disorders, and active inflammatory bowel disease 4) Patients with psychiatric history who cannot cooperate. 5) Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bowel cleanliness (Boston Bowel Preparedness Rating Scale, Ottawa Bowel Preparedness Rating Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| Total incidence of adverse reactions: nausea and vomiting, abdominal pain and distension, dizziness and headache, weakness and fatigue;Entry time, withdrawal time;Detection rate of intestinal lesions;Willingness to repeat bowel preparation;Tolerance of the bowel preparation process; | — |
Countries
China
Contacts
Public ContactHongliang Li
The Affiliated People’s Hospital of Ningbo University
Outcome results
None listed