Sarcopenia of non-small cell lung cancer
Conditions
Interventions
Experimental group:functional exercise matrix intervention
Control group:Regular exercise (Cardio + resistance exercise)
Sponsors
Hainan Cancer Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Pathologically or cytologically confirmed diagnosis of non-small cell lung cancer, without differentiation of disease stage, diagnosed more than 6 weeks ago, having received more than 1 course of oncologic combination therapy and currently receiving chemotherapy, targeted therapy, or immunotherapy in progress; 2. Meet the pre-sarcopenia or sarcopenia stage: According to the Asian Sarcopenia Working Group's 2019 update of the consensus on the diagnosis and treatment of sarcopenia, those with (1) are diagnosed as pre-sarcopenia; Sarcopenia is diagnosed with (1)+(2) or (1)+(3) : (1) Muscle mass: relative limb skeletal muscle mass index: male < 7.0 kg/m2, female < 5.7 kg/m2; (2) Muscle strength: grip strength (HS), male < 28 kg, female < 18 kg; (3) Indicators of muscle function decline: walking speed (GS), GS < 1.0 m/s; 3. 40 years <= age <= 75 years; 4. The ECOG score is 0-2 points (2 points: can walk freely and take care of oneself, but has lost the ability to work, can get up and do activities for at least half of the day), and the expected survival time is more than 6 months; 5. Normal cognitive function and ability to cooperate with exercise training; 6. No implantable cardiac device, such as a pacemaker, is prohibited in bioelectrical impedance analysis (BIA); 7. No functional impairment of the lower limbs and able to walk for at least 6 minutes; 8. Be able to understand Mandarin, complete a questionnaire and be willing to participate in an exercise training program; 9. Patients who understood the purpose of the study and agreed to participate and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe bone or central nervous system metastasis; 2. The patient developed prolonged myelosuppression; 3. Symptomatic heart disease such as uncontrolled high blood pressure or unstable coronary artery disease; 4. Anemia (hemoglobin < 10 g/dL); 5. Lung diseases other than lung cancer, such as chronic obstructive pulmonary disease, tuberculosis, etc. diagnosed within the past three months; 6. Regular physical activity (at least 150 minutes per week at a moderate or higher intensity) within the past 6 months; 7. Suffered from neurological diseases such as stroke and Parkinson's in the past; 8. Unable to complete standardized exercise due to surgical incision, trauma, fracture, severe cancer-related pain and other physical reasons; 9. Patients with active nervous system, substance abuse and/or mental illness; 10. Failure to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short Physical Performance Battery;Appendicular skeletal muscle mass;Grip strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps muscle thickness;Six-minute walk test;Hospital anxiety and depression scale;Chinese Version of the Sarcopenia and Quality of Life, a Quality of Life Questionnaire;Cancer Fatigue Scale;Functional Reaching Test; | — |
Countries
China
Contacts
Public ContactLili Chen
Hainan Cancer Hospital
Outcome results
None listed