The Effect of Intrapartum Antibiotic Prophylaxis to Prevent Group B Streptococcal Early-onset Disease on Maternal Vaginal Microbiome, Intestinal Microbiome and Immunity of Offspring

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200057279

Enrollment

Unknown

Registered

2022-03-06

Start date

2022-03-01

Completion date

Unknown

Last updated

2023-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colonization of Group B Streptococcus

Interventions

Experimental group:

Control group:

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Pregnant women are 18 to 40 years; 2. 35 to 41 weeks of pregnancy; 3. Singleton pregnancy; 4. Plan for vaginal delivery and postpartum care in the research hospital; 5. Pregnant women who volunteered to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Have infectious diseases, serious infections and clinical diseases; 2. Use of antibiotics in the past 2 weeks; 3. Long-term use of drugs due to digestion, immunity, blood, chronic diseases; 4. Sexual behavior, vaginal douching and topical medication within 24 hours before sampling; 5. Any medical or non-medical condition that the investigator considers inappropriate to participate.

Design outcomes

Primary

Measure	Time frame
Microbiology;	—

Secondary

Measure	Time frame
Immunoassay;Cultivate GBS;	—

Countries

China

Contacts

Public ContactQian Wang

Zhujiang Hospital, Southern Medical University

wangqian@smu.edu.cn+86 20 61643888

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026