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NETs and vWF/ADAMTS13 in the progression of pancreatic necrosis in acute pancreatitis: A prospective clinical study

Mechanism of NETs regulating vWF/ADAMTS13 in acute pancreatitis and its effect on pancreatic necrosis progression

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200057233
Enrollment
Unknown
Registered
2022-03-04
Start date
2022-02-28
Completion date
Unknown
Last updated
2023-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute pancreatitis

Interventions

None listed

Sponsors

Department of Critical Care Medicine, Jinling Hospital Affiliated to Nanjing University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Diagnose acute pancreatitis; 2. Within 48 hours from the onset time; 3. Admitted into ICU.

Exclusion criteria

Exclusion criteria: 1. Non-first-time acute pancreatitis; 2. The patient has received surgical treatment before admission; 3. The patient has a known history of blood system diseases; 4. Have a recent history of myocardial infarction or cerebral infarction.

Design outcomes

Primary

MeasureTime frame
ADAMTS13 activity;von Willebrand factor (vWF) polymers;Citrullinated histone H3, CitH3;Peptidyl arginine deiminase 4, PAD4;Circulating free DNA, cf-DNA;area of pancreatic necrosis;—

Countries

China

Contacts

Public ContactLu Ke

Jinling Hospital Affiliated to Nanjing University School of Medicine

ctgkelu@nju.edu.cn+86 15850768312

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026