Postpartum Depression
Conditions
Interventions
Experimental group:Dexmedetomidine 0.5ug/kg +0.9% normal saline was injected intravenously to 20ml for 10min
Control group:0.9% normal saline was injected intravenously to 20ml for 10min
Sponsors
Third Xiangya Hospital, Central South University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Cesarean section with lumbar anesthesia; 2. Aged >=18 years; 3. ASA class II; 4. Gestation >=28 weeks; 5. Request postoperative analgesic treatment; 6. Preoperative Edinburgh Postpartum Depression Scale (EPDS) score >=10; 7. The puerpera can communicate well with the interviewees, voluntarily participate in this study and sign relevant informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergic to a2-receptor agonists; 2. The estimated intraoperative blood loss was more than 800 ml; 3. Preoperative heart rate less than 50 beats/min, abnormal cardiac conduction or rhythm; 4. Hypotension (systolic blood pressure less than 90 MMHG and/or diastolic pressure less than 60 MMHG); 5. Unstable mental illness or depressive illness; 6. A history of abuse of psychotropic drugs and alcohol; 7. Long-term use of certain medications in the 6 months prior to the study; 8. Participate in other clinical drug experiments; 9. Cases deemed inappropriate for collection by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postpartum depression; | — |
Countries
China
Contacts
Public ContactWang Saiying, Duan Kaiming
Third Xiangya Hospital, Central South University
Outcome results
None listed