Pulmonary hypertension of congenital heart disease
Conditions
Interventions
Experimental group:Concomitant transthoracic radiofrequency pulmonary denervation with precardiac correction
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-75 years, no gender limit; 2. Confirmed diagnosis of congenital heart disease with pulmonary hypertension: echocardiographic confirmation was limited to the presence of ventricular septal defect, atrial septal defect, patent ductus arteriosus, endocardial pad defect, anomalous pulmonary vein drainage and other signs of congenital heart disease, and right heart catheterization confirmed mPAP>=25 MMHG and PVR>3 Wood uints.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindication to cardiac surgery, such as severe heart failure, severe systemic infection or fever, severe renal insufficiency, severe anemia or active bleeding, intolerant of anticoagulant therapy, psychiatric patients who cannot cooperate with surgery and PAWP>15mmHg; 2. Have participated in any other clinical trial for pulmonary hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary vascular resistance;Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean pulmonary artery pressure;Pulmonary artery systolic pressure;Diastolic pulmonary artery pressure;BNP/NT-proBNP;6 minutes walk time; | — |
Countries
China
Contacts
Public ContactDong Wenpeng
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed