Alzheimer's disease (AD) complicated with depression
Conditions
Interventions
Group 1:use Alzheimer's medicine alone
Group 2:use Alzheimer's medicine combined with sertraline
Group 3:use Alzheimer's medicine combined with paroxetine
Group 4:use Alzheimer's medicine combined with dutoxetine
Sponsors
Ningbo Kangning Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. AD patients with depression (according to ICD-10 diagnostic criteria) admitted to Ningbo Kangning Hospital from April 2022 to November 2024, aged > 18 years; 2. The Mini-Mental State Examination (MMSE) or Montreal Cognitive Assessment (MoCA) indicated cognitive impairment, and the 24-item Hamilton Depression Scale (HAMD24) score was >=9.
Exclusion criteria
Exclusion criteria: 1. Cerebrovascular diseases or other diseases that may affect brain structure and function, such as multiple intracranial cerebral aneurysms, acute massive cerebral infarction and epilepsy; 2. Unstable or severe heart, lung, liver, kidney, hematopoietic system diseases or severe drug allergy; 3. Drug dependence or serious suicidality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychological scales score;Near-infrared imaging (resting-state, language testing task, Working memory task);Blood (hormones (adrenocorticotropic hormone), inflammatory indicators (interleukin-6, serum amyloid, procalcitonin), BDNF, Aß); | — |
Countries
China
Contacts
Public ContactHuang Ling
Ningbo Kangning Hospital
Outcome results
None listed