Aphasia after stroke
Conditions
Interventions
Group A:Neurotomy of C7 nerve at intervertebral foramen and intensive speech and language therapy
Group B:Intensive speech and language therapy
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Magnetic resonance imaging confirmed left hemisphere cerebral infarction/hemorrhage, aphasia after single onset, onset more than 12 months; 2. Aged 40-65 years, right-handed, native Chinese, no gender limit; 3. The aphasia quotient of WAB score was less than 93.8; 4. BDAE severity level 1 or above; 5. Strong compliance, can cooperate with language rehabilitation training; 6. Be able to fully understand and agree with the doctor's treatment plan, and sign the informed consent. The third and fourth points should be diagnosed by two attending or above specialists respectively.
Exclusion criteria
Exclusion criteria: 1. Contraindications of surgery for any reason as judged by a qualified anesthesiologist or clinician; 2. Patients with aphasia history before the onset of stroke; 3. Severe, untreated mental illness; 4. Aphasia due to degenerative neurological diseases or brain trauma; 5. Contraindications of EEG and MRI; 6. Inability to complete the assessments and rehabilitation required per study design; 7. Severe motor speech disorder and hearing impairment; 8. Received intensive post-stroke rehabilitation therapy 4 weeks before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of Boston Naming Test Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in ICF Speech and Language Function Assessment Score;Changes of Western Aphasia Battery Score;Changes of Activity of Daily Living Scale, ADL;Changes of Communication Activity of Daily Living Scale;Change in post-stroke Depression Scale/Hamilton Depression Scale; | — |
Countries
China
Contacts
Public ContactXu Wendong
Huashan Hospital, Fudan University
Outcome results
None listed