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Efficacy and safety of colistin sulfate as an organ preservation solution decontamination protocol to reduce donor-derived infections caused by drug-resistant bacteria: a prospective, single-group, target-value clinical trial

Efficacy and safety of colistin sulfate as an organ preservation solution decontamination protocol to reduce donor-derived infections caused by drug-resistant bacteria: a prospective, single-group, target-value clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200057172
Enrollment
Unknown
Registered
2022-03-02
Start date
2022-04-01
Completion date
Unknown
Last updated
2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

donor derived infection

Interventions

Experimental group:Colistin sulfate was added to the preservation solution for kidney immersion and perfusion

Sponsors

Shanghai Changhai Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Adult kidney transplant recipients aged 18-60 years; 2. Sign the informed consent voluntarily.

Exclusion criteria

Exclusion criteria: 1. The recipient of kidney transplantation has a history of second or multiple kidney transplantation, and a history of transplantation of other organs and tissues; 2. Renal transplant recipients had a history of colistin sulfate E hypersensitivity; 3. Renal transplant recipients with bacterial infection at any location before transplantation; 4. The operation was cancelled due to various reasons; 5. Renal transplant recipients had preoperative immune deficiencies, such as granulocytosis (absolute granulocyte count <10^3 neutrophils/mm^3).

Design outcomes

Primary

MeasureTime frame
Possible donor-derived Infection events (p-DDI);

Secondary

MeasureTime frame
Infection events in kidney transplant recipients (non-P-DDIs);Length of stay;Deaths from infection;

Countries

China

Contacts

Public ContactZeng Li
zengli111109@163.com+86 13601618099

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026