Thyroid cancer
Conditions
Interventions
Gold Standard:Pathological diagnosis of central lymph nodes
Index test:Preoperative B-ultrasound, preoperative fine needle aspiration, gene mutation determination, postoperative pathology
Sponsors
Shanghai Jiao Tong University Medical Ninth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Part I Research: (1) Patients with papillary thyroid carcinoma, non-locally advanced, no distant metastasis, no history of thyroid cancer surgery; (2) No regional lymph node metastasis was found by preoperative B-ultrasound examination; (3) Willing to undergo gene mutation testing in tumor tissue after surgery. 2. The second part: (1) Patients with papillary thyroid carcinoma; (2) Preoperative imaging examination showed no cervical lymph node metastasis (CLNM); (3) Willing to accept preoperative FNA puncture biopsy and gene mutation detection of puncture fluid; (4) Postoperative pathology confirmed PTC.
Exclusion criteria
Exclusion criteria: 1. Part I Research: (1) Postoperative pathological diagnosis of non-PTC thyroid carcinoma: medullary carcinoma, undifferentiated carcinoma, poorly differentiated carcinoma and squamous cell carcinoma; (2) Patients who did not undergo preventive lymph node dissection. 2. The second part: (1) Locally advanced stage, distant metastasis, thyroid cancer surgery history; (2) Unwilling to accept prophylactic lymph node dissection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| central lymph node metastasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;positive predictive value;negative predictive value; | — |
Countries
China
Contacts
Public ContactZhu Chenfang
Shanghai Jiao Tong University Medical Ninth People's Hospital
Outcome results
None listed