Bipolar disorder
Conditions
Interventions
Intervention Group:Aerobic exercise
Control Group:Conventional drug therapy
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years, no gender limit; 2. Depressive episode diagnosed as bipolar disorder according to DSM-5; 3. Hamilton Depression Scale score >=17, Young Manic scale score <6; 4. Sufficient audio-visual and oral skills to complete the necessary examinations in the study; 5. Volunteer to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. BMI>=40 kg/m^2; 2. Systolic blood pressure >=140mmhg or diastolic blood pressure >=160mm Hg; 3. Perinatal or lactation period; 4. Exercise more than 150 minutes per week in the past six months; 5. Serious physical diseases (heart disease, diabetes, thyroid disease, etc.); 6. Infectious diseases, autoimmune diseases, anti-inflammatory drugs, cortisol hormones and antibiotics in the 4 weeks before enrollment; 7. Severe impulsivity or suicide attempts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale 17 items; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-6 (IL-6);Tumor necrosis factor (TNF-a);C-reactive protein (CRP);Young Mania Rating Scale (YMRS);Self-rating Depression Scale ;Clinical Global Impression Scale; | — |
Countries
China
Contacts
Public ContactLuo Qinghua
Outcome results
None listed